Cargando…

Effect of Matrine on HPAC cell migration by down-regulating the expression of MT1-MMP via Wnt signaling

AIM: This study sought to explore the exact mechanism of Matrine inhibited migration and invasion of human pancreatic cancer cells. METHODS: HPAC or Capan-1 cells were cultured in completed RPMI-1640 medium, contained with 50 μg/ml Matrine or 0.05 μg/ml docetaxel, respectively. Cell viability was ev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Yongchao, Zou, Fazhang, Xiong, Junping, Wan, Wei, Yin, Li, Li, Xianjia, Bei, Zhanyu, Yuan, Lei, Meng, Song, Wang, Jianguo, Song, Guohua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480578/ https://www.ncbi.nlm.nih.gov/pubmed/26113801 http://dx.doi.org/10.1186/s12935-015-0210-4

Ejemplares similares

Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours
por: Tan, Mei Lin, et al.
Publicado: (2010)

Matrine combined with cisplatin synergistically inhibited urothelial bladder cancer cells via down-regulating VEGF/PI3K/Akt signaling pathway
por: Liao, Xiao-Zhong, et al.
Publicado: (2017)

MT1-MMP in breast cancer: induction of VEGF-C correlates with metastasis and poor prognosis
por: Yao, Guangyu, et al.
Publicado: (2013)

Comparative metabolomic analysis of HPAC cells following the acquisition of erlotinib resistance
por: Lee, Sooyeun, et al.
Publicado: (2017)

TIMELESS inhibits breast cancer cell invasion and metastasis by down-regulating the expression of MMP9
por: Li, Bowen, et al.
Publicado: (2021)

HpaC Controls Substrate Specificity of the Xanthomonas Type III Secretion System
por: Lorenz, Christian, et al.
Publicado: (2008)

DKK1 inhibits breast cancer cell migration and invasion through suppression of β-catenin/MMP7 signaling pathway
por: Niu, Jie, et al.
Publicado: (2019)

High threshold of β1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP) activation of matrix metalloproteinase 2 (MMP-2)
por: Borrirukwanit, Kulrut, et al.
Publicado: (2014)

Matrine inhibits cell growth, migration, invasion and promotes autophagy in hepatocellular carcinoma by regulation of circ_0027345/miR-345-5p/HOXD3 axis
por: Lin, Shaobing, et al.
Publicado: (2020)

Long non-coding RNA LINC01314 represses cell migration, invasion, and angiogenesis in gastric cancer via the Wnt/β-catenin signaling pathway by down-regulating KLK4
por: Tang, Lin, et al.
Publicado: (2019)

Interaction of HE4 and ANXA2 exists in various malignant cells—HE4–ANXA2–MMP2 protein complex promotes cell migration
por: Wang, Jing, et al.
Publicado: (2019)

Phenyllactic acid promotes cell migration and invasion in cervical cancer via IKK/NF-κB-mediated MMP-9 activation
por: Li, Chao, et al.
Publicado: (2019)

Upregulation of SPOCK2 inhibits the invasion and migration of prostate cancer cells by regulating the MT1-MMP/MMP2 pathway
por: Liu, Gang, et al.
Publicado: (2019)

A furin inhibitor downregulates osteosarcoma cell migration by downregulating the expression levels of MT1-MMP via the Wnt signaling pathway
por: LIU, BINGSHAN, et al.
Publicado: (2014)

miR-22 is down-regulated in esophageal squamous cell carcinoma and inhibits cell migration and invasion
por: Yang, Chao, et al.
Publicado: (2014)

ROR2 receptor promotes the migration of osteosarcoma cells in response to Wnt5a
por: Dai, Bin, et al.
Publicado: (2017)

miR-324-3p suppresses migration and invasion by targeting WNT2B in nasopharyngeal carcinoma
por: Liu, Chao, et al.
Publicado: (2017)

NCAPG facilitates colorectal cancer cell proliferation, migration, invasion and epithelial–mesenchymal transition by activating the Wnt/β-catenin signaling pathway
por: Shi, Yanlong, et al.
Publicado: (2022)

Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2
por: Wu, Lichuan, et al.
Publicado: (2016)

Wnt5a promotes migration of human osteosarcoma cells by triggering a phosphatidylinositol-3 kinase/Akt signals
por: Zhang, Ailiang, et al.
Publicado: (2014)

Oridonin inhibits pancreatic cancer cell migration and epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling pathway
por: Liu, Qian-Qian, et al.
Publicado: (2016)

Cytoplasmic Tail of MT1-MMP: A Hub of MT1-MMP Regulation and Function
por: Strouhalova, Katerina, et al.
Publicado: (2023)

MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms
por: Gifford, Valentina, et al.
Publicado: (2019)

CircMMP11 regulates proliferation, migration, invasion, and apoptosis of breast cancer cells through miR-625-5p/ZEB2 axis
por: Qi, Liqiang, et al.
Publicado: (2021)

TACR2 is associated with the immune microenvironment and inhibits migration and proliferation via the Wnt/β-catenin signaling pathway in prostate cancer
por: Jianfeng, Wang, et al.
Publicado: (2021)

ADAM17 promotes the invasion of hepatocellular carcinoma via upregulation MMP21
por: Xiang, Yuqi, et al.
Publicado: (2020)

Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives
por: Li, Jinlei, et al.
Publicado: (2023)

Down-regulation of TRIB3 inhibits the progression of ovarian cancer via MEK/ERK signaling pathway
por: Wang, Shuang, et al.
Publicado: (2020)

Downregulation of Tim-1 inhibits the proliferation, migration and invasion of glioblastoma cells via the miR-133a/TGFBR1 axis and the restriction of Wnt/β-catenin pathway
por: Wei, Li, et al.
Publicado: (2021)

Knockdown of AGGF1 inhibits the invasion and migration of gastric cancer via epithelial–mesenchymal transition through Wnt/β-catenin pathway
por: Yao, Han-Hui, et al.
Publicado: (2019)

PI3Kα isoform-dependent activation of RhoA regulates Wnt5a-induced osteosarcoma cell migration
por: Zhang, Ailiang, et al.
Publicado: (2017)

LncRNA CBR3-AS1 potentiates Wnt/β-catenin signaling to regulate lung adenocarcinoma cells proliferation, migration and invasion
por: Hou, Min, et al.
Publicado: (2021)

MiR-539 inhibits proliferation and migration of triple-negative breast cancer cells by down-regulating LAMA4 expression
por: Yang, Zhi-Xue, et al.
Publicado: (2018)

EphA5 knockdown enhances the invasion and migration ability of esophageal squamous cell carcinoma via epithelial-mesenchymal transition through activating Wnt/β-catenin pathway
por: Zhang, Rui, et al.
Publicado: (2020)

Down-regulation of DNMT3b in PC3 cells effects locus-specific DNA methylation, and represses cellular growth and migration
por: Yaqinuddin, Ahmed, et al.
Publicado: (2008)

The lncRNA DLX6-AS1 promoted cell proliferation, invasion, migration and epithelial-to-mesenchymal transition in bladder cancer via modulating Wnt/β-catenin signaling pathway
por: Guo, Jinan, et al.
Publicado: (2019)

Up-regulation of microRNA-200c-3p inhibits invasion and migration of renal cell carcinoma cells via the SOX2-dependent Wnt/β-catenin signaling pathway
por: Li, Shuai, et al.
Publicado: (2019)

LncRNA FLVCR1-AS1 promotes proliferation, migration and activates Wnt/β-catenin pathway through miR-381-3p/CTNNB1 axis in breast cancer
por: Pan, Zhiyu, et al.
Publicado: (2020)

MAP7 promotes migration and invasion and progression of human cervical cancer through modulating the autophagy
por: Zhang, Li, et al.
Publicado: (2020)

Identification of the prognostic value of a 2-gene signature of the WNT gene family in UCEC using bioinformatics and real-world data
por: Hu, Yuexin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0vc30mo6lrhldbem39qfe4dk7l