Optimized zein nanospheres for improved oral bioavailability of atorvastatin

BACKGROUND: This work focuses on the development of atorvastatin utilizing zein, a natural, safe, and biocompatible polymer, as a nanosized formulation in order to overcome the poor oral bioavailability (12%) of the drug. METHODS: Twelve experimental runs of atorvastatin–zein nanosphere formula were...

Descripción completa

Detalles Bibliográficos
Autores principales: Hashem, Fahima M, Al-Sawahli, Majid M, Nasr, Mohamed, Ahmed, Osama AA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480588/
https://www.ncbi.nlm.nih.gov/pubmed/26150716
http://dx.doi.org/10.2147/IJN.S83906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480588/
https://www.ncbi.nlm.nih.gov/pubmed/26150716
http://dx.doi.org/10.2147/IJN.S83906

Ejemplares similares