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Optimized zein nanospheres for improved oral bioavailability of atorvastatin

BACKGROUND: This work focuses on the development of atorvastatin utilizing zein, a natural, safe, and biocompatible polymer, as a nanosized formulation in order to overcome the poor oral bioavailability (12%) of the drug. METHODS: Twelve experimental runs of atorvastatin–zein nanosphere formula were...

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Detalles Bibliográficos
Autores principales:	Hashem, Fahima M, Al-Sawahli, Majid M, Nasr, Mohamed, Ahmed, Osama AA
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480588/ https://www.ncbi.nlm.nih.gov/pubmed/26150716 http://dx.doi.org/10.2147/IJN.S83906

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