Modafinil and its metabolites enhance the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model

RATIONALE: Seizures occur when the excitability of brain circuits is not sufficiently restrained by inhibitory mechanisms. Although modafinil is reported to reduce GABA-activated currents and extracellular GABA levels in the brain, the drug exerts anticonvulsant effects in animal studies. OBJECTIVES...

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Detalles Bibliográficos
Autores principales: Zolkowska, Dorota, Andres-Mach, Marta, Prisinzano, Thomas E., Baumann, Michael H., Luszczki, Jarogniew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480820/
https://www.ncbi.nlm.nih.gov/pubmed/25697861
http://dx.doi.org/10.1007/s00213-015-3884-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480820/
https://www.ncbi.nlm.nih.gov/pubmed/25697861
http://dx.doi.org/10.1007/s00213-015-3884-3

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