Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

Troglitazone (TGZ) caused delayed, life-threatening drug-induced liver injury (DILI) in some patients, but was not hepatotoxic in rats. This study investigated altered bile acid (BA) homeostasis as a mechanism of TGZ hepatotoxicity using a systems pharmacology model incorporating drug/metabolite dis...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Kyunghee, Woodhead, Jeffrey L, Watkins, Paul B, Howell, Brett A, Brouwer, Kim LR
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480860/
https://www.ncbi.nlm.nih.gov/pubmed/25068506
http://dx.doi.org/10.1038/clpt.2014.158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480860/
https://www.ncbi.nlm.nih.gov/pubmed/25068506
http://dx.doi.org/10.1038/clpt.2014.158

Ejemplares similares