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Widespread intron retention diversifies most cancer transcriptomes
BACKGROUND: Somatic mutations affecting components of the RNA splicing machinery occur with high frequencies across many tumor types. These mutations give rise to distinct alterations in normal splice site and exon recognition, such as unusual 3′ splice site preferences, that likely contribute to tu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480902/ https://www.ncbi.nlm.nih.gov/pubmed/26113877 http://dx.doi.org/10.1186/s13073-015-0168-9 |