Enzyme assays for synthesis and degradation of 2-5As and other 2′-5′ oligonucleotides

BACKGROUND: The 5′-triphosphorylated, 2′-5′-linked oligoadenylate polyribonucleotides (2-5As) are central to the interferon-induced antiviral 2-5A system. The 2-5As bind and activate the RNase L, an endoRNase degrading viral and cellular RNA leading to inhibition of viral replication. The 2-5A syste...

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Detalles Bibliográficos
Autores principales: Poulsen, Jesper Buchhave, Kjær, Karina Hansen, Justesen, Just, Martensen, Pia Møller
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481073/
https://www.ncbi.nlm.nih.gov/pubmed/26113370
http://dx.doi.org/10.1186/s12858-015-0043-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481073/
https://www.ncbi.nlm.nih.gov/pubmed/26113370
http://dx.doi.org/10.1186/s12858-015-0043-8

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