MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end-resection

Appropriate repair of DNA lesions and the inhibition of DNA repair activities at telomeres are critical to prevent genomic instability. By fuelling the generation of genetic alterations and by compromising cell viability, genomic instability is a driving force in cancer and aging(1, 2). Here we iden...

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Detalles Bibliográficos
Autores principales: Boersma, Vera, Moatti, Nathalie, Segura-Bayona, Sandra, Peuscher, Marieke H., van der Torre, Jaco, Wevers, Brigitte A., Orthwein, Alexandre, Durocher, Daniel, Jacobs, Jacqueline J.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481296/
https://www.ncbi.nlm.nih.gov/pubmed/25799990
http://dx.doi.org/10.1038/nature14216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481296/
https://www.ncbi.nlm.nih.gov/pubmed/25799990
http://dx.doi.org/10.1038/nature14216

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