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MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end-resection
Appropriate repair of DNA lesions and the inhibition of DNA repair activities at telomeres are critical to prevent genomic instability. By fuelling the generation of genetic alterations and by compromising cell viability, genomic instability is a driving force in cancer and aging(1, 2). Here we iden...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481296/ https://www.ncbi.nlm.nih.gov/pubmed/25799990 http://dx.doi.org/10.1038/nature14216 |