Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets

The fatty acid amide hydrolase (FAAH) regulates the endocannabinoid system cleaving primarily the lipid messenger anandamide. FAAH has been well characterized over the years and, importantly, it represents a promising drug target to treat several diseases, including inflammatory-related diseases and...

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Detalles Bibliográficos
Autores principales: Palermo, Giulia, Bauer, Inga, Campomanes, Pablo, Cavalli, Andrea, Armirotti, Andrea, Girotto, Stefania, Rothlisberger, Ursula, De Vivo, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481349/
https://www.ncbi.nlm.nih.gov/pubmed/26111155
http://dx.doi.org/10.1371/journal.pcbi.1004231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481349/
https://www.ncbi.nlm.nih.gov/pubmed/26111155
http://dx.doi.org/10.1371/journal.pcbi.1004231

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