Cargando…

Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets

The fatty acid amide hydrolase (FAAH) regulates the endocannabinoid system cleaving primarily the lipid messenger anandamide. FAAH has been well characterized over the years and, importantly, it represents a promising drug target to treat several diseases, including inflammatory-related diseases and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Palermo, Giulia, Bauer, Inga, Campomanes, Pablo, Cavalli, Andrea, Armirotti, Andrea, Girotto, Stefania, Rothlisberger, Ursula, De Vivo, Marco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481349/ https://www.ncbi.nlm.nih.gov/pubmed/26111155 http://dx.doi.org/10.1371/journal.pcbi.1004231

Ejemplares similares

The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition
por: Palermo, Giulia, et al.
Publicado: (2015)

Discovery of processive catalysis by an exo-hydrolase with a pocket-shaped active site
por: Streltsov, Victor A., et al.
Publicado: (2019)

Benzoxazolone Carboxamides: Potent and Systemically Active Inhibitors of Intracellular Acid Ceramidase**
por: Pizzirani, Daniela, et al.
Publicado: (2015)

Crystal structures of Moorella thermoacetica cyanuric acid hydrolase reveal conformational flexibility and asymmetry important for catalysis
por: Shi, Ke, et al.
Publicado: (2019)

Epigenetic Regulation of Fatty Acid Amide Hydrolase in Alzheimer Disease
por: D'Addario, Claudio, et al.
Publicado: (2012)

Decarbonylative Borylation of Amides by Palladium Catalysis
por: Shi, Shicheng, et al.
Publicado: (2019)

Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors
por: Kodani, Sean D., et al.
Publicado: (2018)

Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety
por: Carnevali, Luca, et al.
Publicado: (2015)

A Catalytic Mechanism for Cysteine N-Terminal Nucleophile Hydrolases, as Revealed by Free Energy Simulations
por: Lodola, Alessio, et al.
Publicado: (2012)

Molecular Recognition by Gold Nanoparticle-Based Receptors as Defined through Surface Morphology and Pockets Fingerprint
por: Riccardi, Laura, et al.
Publicado: (2021)

Luciferin Amides Enable in Vivo Bioluminescence Detection of Endogenous Fatty Acid Amide Hydrolase Activity
por: Mofford, David M., et al.
Publicado: (2015)

Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen
por: Deplano, Alessandro, et al.
Publicado: (2020)

A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase
por: Carey, Lawrence M, et al.
Publicado: (2016)

Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors
por: Deplano, Alessandro, et al.
Publicado: (2019)

Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase
por: Qiu, Yan, et al.
Publicado: (2016)

Role of Steroids on the Membrane Binding Ability of Fatty Acid Amide Hydrolase
por: Sabatucci, Annalaura, et al.
Publicado: (2019)

Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase
por: Ito, Kosuke, et al.
Publicado: (2012)

C7‐Indole Amidations and Alkenylations by Ruthenium(II) Catalysis
por: Choi, Isaac, et al.
Publicado: (2020)

Cellular viability effects of fatty acid amide hydrolase inhibition on cerebellar neurons
por: Lueneberg, Kathia, et al.
Publicado: (2011)

Overexpression of Fatty Acid Amide Hydrolase Induces Early Flowering in Arabidopsis thaliana
por: Teaster, Neal D., et al.
Publicado: (2012)

Inhibition of Vascular Growth by Modulation of the Anandamide/Fatty Acid Amide Hydrolase Axis
por: Rieck, Sarah, et al.
Publicado: (2021)

Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer
por: Tundidor, Isabel, et al.
Publicado: (2023)

Evolutionary adaptation from hydrolytic to oxygenolytic catalysis at the α/β-hydrolase fold
por: Bui, Soi, et al.
Publicado: (2023)

Involvement of Fatty Acid Amide Hydrolase and Fatty Acid Binding Protein 5 in the Uptake of Anandamide by Cell Lines with Different Levels of Fatty Acid Amide Hydrolase Expression: A Pharmacological Study
por: Björklund, Emmelie, et al.
Publicado: (2014)

Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2
por: Sgrignani, Jacopo, et al.
Publicado: (2021)

Fatty Acid Amide Hydrolase (FAAH) Inhibition Plays a Key Role in Counteracting Acute Lung Injury
por: Genovese, Tiziana, et al.
Publicado: (2022)

The role of ligand-gated conformational changes in enzyme catalysis
por: Moreira, Cátia, et al.
Publicado: (2019)

Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice
por: Cassano, Tommaso, et al.
Publicado: (2010)

Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms
por: Sirrs, Sandra, et al.
Publicado: (2015)

Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants
por: Ogawa, Shintaro, et al.
Publicado: (2015)

PET Imaging of Fatty Acid Amide Hydrolase with [(18)F]DOPP in Nonhuman Primates
por: Rotstein, Benjamin H., et al.
Publicado: (2014)

The fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B shedding
por: Sekiba, Kazuma, et al.
Publicado: (2020)

Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10‐2474
por: Bonifácio, Maria‐João, et al.
Publicado: (2020)

Fatty acid amide hydrolase levels in brain linked with threat-related amygdala activation
por: Green, Duncan GJ., et al.
Publicado: (2022)

Substrate recognition and catalysis by LytB, a pneumococcal peptidoglycan hydrolase involved in virulence
por: Rico-Lastres, Palma, et al.
Publicado: (2015)

Hydrolase–like catalysis and structural resolution of natural products by a metal–organic framework
por: Mon, Marta, et al.
Publicado: (2020)

Site-specific Umpolung amidation of carboxylic acids via triplet synergistic catalysis
por: Ning, Yunyun, et al.
Publicado: (2021)

Hydrogenation of Secondary Amides using Phosphane Oxide and Frustrated Lewis Pair Catalysis
por: Köring, Laura, et al.
Publicado: (2021)

Prediction of distal residue participation in enzyme catalysis
por: Brodkin, Heather R, et al.
Publicado: (2015)

Dysfunction in Fatty Acid Amide Hydrolase Is Associated with Depressive-Like Behavior in Wistar Kyoto Rats
por: Vinod, K. Yaragudri, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_9rgji1mou6lrs9h97nna5e5sp2