Enrichment of the Cancer Stem Phenotype in Sphere Cultures of Prostate Cancer Cell Lines Occurs through Activation of Developmental Pathways Mediated by the Transcriptional Regulator ΔNp63α

BACKGROUND: Cancer stem cells (CSC) drive prostate cancer tumor survival and metastasis. Nevertheless, the development of specific therapies against CSCs is hindered by the scarcity of these cells in prostate tissues. Suspension culture systems have been reported to enrich CSCs in primary cultures a...

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Detalles Bibliográficos
Autores principales: Portillo-Lara, Roberto, Alvarez, Mario Moisés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481544/
https://www.ncbi.nlm.nih.gov/pubmed/26110651
http://dx.doi.org/10.1371/journal.pone.0130118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481544/
https://www.ncbi.nlm.nih.gov/pubmed/26110651
http://dx.doi.org/10.1371/journal.pone.0130118

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