Cargando…

Caffeine/sleep-deprivation interaction in mice produces complex memory effects

BACKGROUND: Sleep deprivation negatively impacts memory, causing deficits in memory processes. Of interest is any agent that can offset such deficits. Mice were given varying doses of caffeine for 14 days and then deprived of sleep for 6 hours by the ‘gentle handling’ method. Memory was assessed usi...

Descripción completa

Detalles Bibliográficos
Autores principales: Onaolapo, Olakunle J, Onaolapo, Adejoke Y, Akanmu, Moses A, Olayiwola, Gbola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Indian Academy of Neurosciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481547/
https://www.ncbi.nlm.nih.gov/pubmed/26130922
http://dx.doi.org/10.5214/ans.0972.7531.220304
_version_ 1782378292977860608
author Onaolapo, Olakunle J
Onaolapo, Adejoke Y
Akanmu, Moses A
Olayiwola, Gbola
author_facet Onaolapo, Olakunle J
Onaolapo, Adejoke Y
Akanmu, Moses A
Olayiwola, Gbola
author_sort Onaolapo, Olakunle J
collection PubMed
description BACKGROUND: Sleep deprivation negatively impacts memory, causing deficits in memory processes. Of interest is any agent that can offset such deficits. Mice were given varying doses of caffeine for 14 days and then deprived of sleep for 6 hours by the ‘gentle handling’ method. Memory was assessed using the Novel Object Recognition Test and Y maze alternation. PURPOSE: The study was designed to ascertain the impact of varying doses of caffeine combined with total sleep-deprivation on spatial and non spatial memory in mice. METHODS: Adult Swiss Webster mice of both sexes were assigned to six groups viz., vehicle (distilled water), or one of five selected doses of caffeine (10, 20, 40, 80 and 120 mg/kg) for 14 days via the oral route. Open field novel object recognition test and Y maze spatial working memory tests were carried out on day 14. Results were analysed using multi-factorial ANOVA followed by Tukey HSD test and expressed as mean ± S.E.M, with p values less than 0.05 were considered statistically significant. RESULTS: Novel object recognition tests (NOR) revealed that pre-training and pre-test sleep deprivation and caffeine combination impaired non spatial and spatial memory in male and female mice. CONCLUSION: The study shows the complex interactions with memory that may arise when total sleep deprivation is superimposed on caffeine administration.
format Online
Article
Text
id pubmed-4481547
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Indian Academy of Neurosciences
record_format MEDLINE/PubMed
spelling pubmed-44815472015-07-01 Caffeine/sleep-deprivation interaction in mice produces complex memory effects Onaolapo, Olakunle J Onaolapo, Adejoke Y Akanmu, Moses A Olayiwola, Gbola Ann Neurosci Research Article BACKGROUND: Sleep deprivation negatively impacts memory, causing deficits in memory processes. Of interest is any agent that can offset such deficits. Mice were given varying doses of caffeine for 14 days and then deprived of sleep for 6 hours by the ‘gentle handling’ method. Memory was assessed using the Novel Object Recognition Test and Y maze alternation. PURPOSE: The study was designed to ascertain the impact of varying doses of caffeine combined with total sleep-deprivation on spatial and non spatial memory in mice. METHODS: Adult Swiss Webster mice of both sexes were assigned to six groups viz., vehicle (distilled water), or one of five selected doses of caffeine (10, 20, 40, 80 and 120 mg/kg) for 14 days via the oral route. Open field novel object recognition test and Y maze spatial working memory tests were carried out on day 14. Results were analysed using multi-factorial ANOVA followed by Tukey HSD test and expressed as mean ± S.E.M, with p values less than 0.05 were considered statistically significant. RESULTS: Novel object recognition tests (NOR) revealed that pre-training and pre-test sleep deprivation and caffeine combination impaired non spatial and spatial memory in male and female mice. CONCLUSION: The study shows the complex interactions with memory that may arise when total sleep deprivation is superimposed on caffeine administration. Indian Academy of Neurosciences 2015-07 /pmc/articles/PMC4481547/ /pubmed/26130922 http://dx.doi.org/10.5214/ans.0972.7531.220304 Text en Copyright © 2015, The National Academy of Sciences http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Onaolapo, Olakunle J
Onaolapo, Adejoke Y
Akanmu, Moses A
Olayiwola, Gbola
Caffeine/sleep-deprivation interaction in mice produces complex memory effects
title Caffeine/sleep-deprivation interaction in mice produces complex memory effects
title_full Caffeine/sleep-deprivation interaction in mice produces complex memory effects
title_fullStr Caffeine/sleep-deprivation interaction in mice produces complex memory effects
title_full_unstemmed Caffeine/sleep-deprivation interaction in mice produces complex memory effects
title_short Caffeine/sleep-deprivation interaction in mice produces complex memory effects
title_sort caffeine/sleep-deprivation interaction in mice produces complex memory effects
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481547/
https://www.ncbi.nlm.nih.gov/pubmed/26130922
http://dx.doi.org/10.5214/ans.0972.7531.220304
work_keys_str_mv AT onaolapoolakunlej caffeinesleepdeprivationinteractioninmiceproducescomplexmemoryeffects
AT onaolapoadejokey caffeinesleepdeprivationinteractioninmiceproducescomplexmemoryeffects
AT akanmumosesa caffeinesleepdeprivationinteractioninmiceproducescomplexmemoryeffects
AT olayiwolagbola caffeinesleepdeprivationinteractioninmiceproducescomplexmemoryeffects