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NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7

BACKGROUND: Although matrix metalloproteinase (MMP)-7 expression is correlated with increased metastatic potential in human colon cancer cells, the underlying molecular mechanism of invasive phenotype remains unknown. In the current study, we investigated the regulatory effects of membrane NADPH oxi...

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Detalles Bibliográficos
Autores principales: Banskota, Suhrid, Regmi, Sushil C., Kim, Jung-Ae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482031/
https://www.ncbi.nlm.nih.gov/pubmed/26116564
http://dx.doi.org/10.1186/s12943-015-0379-0