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multiSNV: a probabilistic approach for improving detection of somatic point mutations from multiple related tumour samples
Somatic variant analysis of a tumour sample and its matched normal has been widely used in cancer research to distinguish germline polymorphisms from somatic mutations. However, due to the extensive intratumour heterogeneity of cancer, sequencing data from a single tumour sample may greatly underest...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482059/ https://www.ncbi.nlm.nih.gov/pubmed/25722372 http://dx.doi.org/10.1093/nar/gkv135 |