2′-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF

Synthetic oligonucleotides are used to regulate gene expression through different mechanisms. Chemical modifications of the backbone of the nucleic acid and/or of the 2′ moiety of the ribose can increase nuclease stability and/or binding affinity of oligonucleotides to target molecules. Here we repo...

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Detalles Bibliográficos
Autores principales: Shen, Wen, Liang, Xue-hai, Sun, Hong, Crooke, Stanley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482069/
https://www.ncbi.nlm.nih.gov/pubmed/25855809
http://dx.doi.org/10.1093/nar/gkv298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482069/
https://www.ncbi.nlm.nih.gov/pubmed/25855809
http://dx.doi.org/10.1093/nar/gkv298

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