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DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation

The E3 ubiquitin ligase HUWE1/Mule/ARF-BP1 plays an important role in integrating/coordinating diverse cellular processes such as DNA damage repair and apoptosis. A previous study has shown that HUWE1 is required for the early step of DNA damage-induced apoptosis, by targeting MCL-1 for proteasomal...

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Detalles Bibliográficos
Autores principales:	Yi, Juan, Lu, Guang, Li, Li, Wang, Xiaozhen, Cao, Li, Lin, Ming, Zhang, Sha, Shao, Genze
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482080/ https://www.ncbi.nlm.nih.gov/pubmed/25883150 http://dx.doi.org/10.1093/nar/gkv325

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