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The effect of RNA base lesions on mRNA translation

The biological effect of oxidatively damaged RNA, unlike oxidatively damaged DNA, has rarely been investigated, although it poses a threat to any living cell. Here we report on the effect of the commonly known RNA base-lesions 8-oxo-rG, 8-oxo-rA, ε-rC, ε-rA, 5-HO-rC, 5-HO-rU and the RNA abasic site...

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Detalles Bibliográficos
Autores principales: Calabretta, Alessandro, Küpfer, Pascal A., Leumann, Christian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482091/
https://www.ncbi.nlm.nih.gov/pubmed/25897124
http://dx.doi.org/10.1093/nar/gkv377