Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism

Background Dopamine (DA) neuron-selective uptake and toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes parkinsonism in humans. Loss of DA neurons via mitochondrial damage and oxidative stress is reproduced by systemic injection of MPTP in animals, which serves as models of parki...

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Detalles Bibliográficos
Autores principales: Kitao, Yasuko, Ageta-Ishihara, Natsumi, Takahashi, Ryosuke, Kinoshita, Makoto, Hori, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2015
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482211/
https://www.ncbi.nlm.nih.gov/pubmed/26167274
http://dx.doi.org/10.12688/f1000research.6386.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482211/
https://www.ncbi.nlm.nih.gov/pubmed/26167274
http://dx.doi.org/10.12688/f1000research.6386.1

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