Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth

While accumulating evidence has shown that the use of the diabetic drug metformin may be beneficial against various tumors in some epidemiological studies, a few studies failed to show the same beneficial effects. The molecular and cellular mechanisms for these conflicting observations are not clear...

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Detalles Bibliográficos
Autores principales: Yang, Hua, Peng, Yuan-Fei, Ni, Hong-Min, Li, Yuan, Shi, Ying-Hong, Ding, Wen-Xing, Fan, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482411/
https://www.ncbi.nlm.nih.gov/pubmed/26111001
http://dx.doi.org/10.1371/journal.pone.0130953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482411/
https://www.ncbi.nlm.nih.gov/pubmed/26111001
http://dx.doi.org/10.1371/journal.pone.0130953

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