The Transmodulation of HER2 and EGFR by Substance P in Breast Cancer Cells Requires c-Src and Metalloproteinase Activation

BACKGROUND: Substance P (SP) is a pleiotropic cytokine/neuropeptide that enhances breast cancer (BC) aggressiveness by transactivating tyrosine kinase receptors like EGFR and HER2. We previously showed that SP and its cognate receptor NK-1 (SP/NK1-R) signaling modulates the basal phosphorylation of...

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Detalles Bibliográficos
Autores principales: Garcia-Recio, Susana, Pastor-Arroyo, Eva M., Marín-Aguilera, Mercedes, Almendro, Vanessa, Gascón, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482606/
https://www.ncbi.nlm.nih.gov/pubmed/26114632
http://dx.doi.org/10.1371/journal.pone.0129661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482606/
https://www.ncbi.nlm.nih.gov/pubmed/26114632
http://dx.doi.org/10.1371/journal.pone.0129661

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