Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS

Neurons are particularly vulnerable to perturbations in endo-lysosomal transport, as several neurological disorders are caused by a primary deficit in this pathway. In this report, we used positional cloning to show that the spontaneously occurring neurological mutation teetering (tn) is a single nu...

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Detalles Bibliográficos
Autores principales: Watson, Jennifer A., Bhattacharyya, Bula J., Vaden, Jada H., Wilson, Julie A., Icyuz, Mert, Howard, Alan D., Phillips, Edward, DeSilva, Tara M., Siegal, Gene P., Bean, Andrew J., King, Gwendalyn D., Phillips, Scott E., Miller, Richard J., Wilson, Scott M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482608/
https://www.ncbi.nlm.nih.gov/pubmed/26115514
http://dx.doi.org/10.1371/journal.pgen.1005290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482608/
https://www.ncbi.nlm.nih.gov/pubmed/26115514
http://dx.doi.org/10.1371/journal.pgen.1005290

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