Phenformin Induces Cell Cycle Change, Apoptosis, and Mesenchymal-Epithelial Transition and Regulates the AMPK/mTOR/p70s6k and MAPK/ERK Pathways in Breast Cancer Cells

Breast cancer remains a world-wide challenge, and additional anti-cancer therapies are still urgently needed. Emerging evidence has demonstrated the potent anti-tumor effect of biguanides, among which phenformin was reported to potentially be a more active anti-cancer agent than metformin. However,...

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Detalles Bibliográficos
Autores principales: Liu, Zhao, Ren, Lidong, Liu, Chenghao, Xia, Tiansong, Zha, Xiaoming, Wang, Shui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482683/
https://www.ncbi.nlm.nih.gov/pubmed/26114294
http://dx.doi.org/10.1371/journal.pone.0131207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482683/
https://www.ncbi.nlm.nih.gov/pubmed/26114294
http://dx.doi.org/10.1371/journal.pone.0131207

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