Mechanisms of Fatal Cardiotoxicity following High-Dose Cyclophosphamide Therapy and a Method for Its Prevention

Observed only after administration of high doses, cardiotoxicity is the dose-limiting effect of cyclophosphamide (CY). We investigated the poorly understood cardiotoxic mechanisms of high-dose CY. A rat cardiac myocardial cell line, H9c2, was exposed to CY metabolized by S9 fraction of rat liver hom...

Descripción completa

Detalles Bibliográficos
Autores principales: Nishikawa, Takuro, Miyahara, Emiko, Kurauchi, Koichiro, Watanabe, Erika, Ikawa, Kazuro, Asaba, Kousuke, Tanabe, Takayuki, Okamoto, Yasuhiro, Kawano, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482695/
https://www.ncbi.nlm.nih.gov/pubmed/26114497
http://dx.doi.org/10.1371/journal.pone.0131394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482695/
https://www.ncbi.nlm.nih.gov/pubmed/26114497
http://dx.doi.org/10.1371/journal.pone.0131394

Ejemplares similares