Cargando…
AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis
Mice lacking DNase II display a polyarthritis-like disease phenotype that is driven by translocation of self-DNA into the cytoplasm of phagocytic cells, where it is sensed by pattern recognition receptors. While pro-inflammatory gene expression is non-redundantly linked to the presence of STING in t...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482750/ https://www.ncbi.nlm.nih.gov/pubmed/26114879 http://dx.doi.org/10.1371/journal.pone.0131702 |