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Detailed assessment of gene activation levels by multiple hypoxia-responsive elements under various hypoxic conditions

OBJECTIVE: HIF-1/HRE pathway is a promising target for the imaging and the treatment of intractable malignancy (HIF-1; hypoxia-inducible factor 1, HRE; hypoxia-responsive element). The purposes of our study are: (1) to assess the gene activation levels resulting from various numbers of HREs under va...

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Detalles Bibliográficos
Autores principales: Takeuchi, Yasuto, Inubushi, Masayuki, Jin, Yong-Nan, Murai, Chika, Tsuji, Atsushi B., Hata, Hironobu, Kitagawa, Yoshimasa, Saga, Tsuneo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483249/
https://www.ncbi.nlm.nih.gov/pubmed/25249501
http://dx.doi.org/10.1007/s12149-014-0901-2