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Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes
Tea contains polyphenols and is one of the most popular beverages consumed worldwide. Because most tyrosinase inhibitors that regulate melanogenesis are phenol/catechol derivatives, this study investigated the inhibitory effects of Camellia sinensis water extracts (CSWEs), including black tea, green...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Veterinary Science
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483495/ https://www.ncbi.nlm.nih.gov/pubmed/25643794 http://dx.doi.org/10.4142/jvs.2015.16.2.135 |
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author | Kim, Young Chul Choi, So Young Park, Eun Ye |
author_facet | Kim, Young Chul Choi, So Young Park, Eun Ye |
author_sort | Kim, Young Chul |
collection | PubMed |
description | Tea contains polyphenols and is one of the most popular beverages consumed worldwide. Because most tyrosinase inhibitors that regulate melanogenesis are phenol/catechol derivatives, this study investigated the inhibitory effects of Camellia sinensis water extracts (CSWEs), including black tea, green tea, and white tea extracts, on melanogenesis using immortalized melanocytes. CSWEs inhibited melanin accumulation and melanin synthesis along with tyrosinase activity in a concentration-dependent manner. These inhibitory effects were superior to those of arbutin, a well-known depigmenting agent. The anti-melanogenic activity of black (fermented) tea was higher than that of a predominant tea catecholamine, epigallocatechin gallate. CSWEs, especially black tea extract, decreased tyrosinase protein levels in a concentration-dependent manner. These results suggest that the anti-melanogenic effect of CSWEs is mediated by a decrease in both tyrosinase activity and protein expression, and may be augmented by fermentation. Thus, CSWEs could be useful skin-whitening agents in the cosmetic industry. |
format | Online Article Text |
id | pubmed-4483495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44834952015-06-29 Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes Kim, Young Chul Choi, So Young Park, Eun Ye J Vet Sci Original Article Tea contains polyphenols and is one of the most popular beverages consumed worldwide. Because most tyrosinase inhibitors that regulate melanogenesis are phenol/catechol derivatives, this study investigated the inhibitory effects of Camellia sinensis water extracts (CSWEs), including black tea, green tea, and white tea extracts, on melanogenesis using immortalized melanocytes. CSWEs inhibited melanin accumulation and melanin synthesis along with tyrosinase activity in a concentration-dependent manner. These inhibitory effects were superior to those of arbutin, a well-known depigmenting agent. The anti-melanogenic activity of black (fermented) tea was higher than that of a predominant tea catecholamine, epigallocatechin gallate. CSWEs, especially black tea extract, decreased tyrosinase protein levels in a concentration-dependent manner. These results suggest that the anti-melanogenic effect of CSWEs is mediated by a decrease in both tyrosinase activity and protein expression, and may be augmented by fermentation. Thus, CSWEs could be useful skin-whitening agents in the cosmetic industry. The Korean Society of Veterinary Science 2015-06 2015-06-17 /pmc/articles/PMC4483495/ /pubmed/25643794 http://dx.doi.org/10.4142/jvs.2015.16.2.135 Text en © 2015 The Korean Society of Veterinary Science. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Young Chul Choi, So Young Park, Eun Ye Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes |
title | Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes |
title_full | Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes |
title_fullStr | Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes |
title_full_unstemmed | Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes |
title_short | Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes |
title_sort | anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483495/ https://www.ncbi.nlm.nih.gov/pubmed/25643794 http://dx.doi.org/10.4142/jvs.2015.16.2.135 |
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