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Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers

Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major regulatory step, an irreversible reaction of oxidative decarboxylation of pyruvate to a...

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Detalles Bibliográficos
Autor principal: Jeoung, Nam Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483603/
https://www.ncbi.nlm.nih.gov/pubmed/26124988
http://dx.doi.org/10.4093/dmj.2015.39.3.188