Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation

Lasonolide A (LSA), a potent antitumor polyketide from the marine sponge, Forcepia sp., induces rapid and reversible protein hyperphosphorylation and premature chromosome condensation (PCC) at nanomolar concentrations independent of cyclin-dependent kinases. To identify cellular targets of LSA, we s...

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Detalles Bibliográficos
Autores principales: Jossé, Rozenn, Zhang, Yong-Wei, Giroux, Valentin, Ghosh, Arun K., Luo, Ji, Pommier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483648/
https://www.ncbi.nlm.nih.gov/pubmed/26058013
http://dx.doi.org/10.3390/md13063625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483648/
https://www.ncbi.nlm.nih.gov/pubmed/26058013
http://dx.doi.org/10.3390/md13063625

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