Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells

The transcription factor brachyury (T, BRA) is one of the first markers of gastrulation and lineage specification in vertebrates. Despite its wide use and importance in stem cell and developmental biology, its functional genomic targets in human cells are largely unknown. Here, we use differentiatin...

Descripción completa

Detalles Bibliográficos
Autores principales: Faial, Tiago, Bernardo, Andreia S., Mendjan, Sasha, Diamanti, Evangelia, Ortmann, Daniel, Gentsch, George E., Mascetti, Victoria L., Trotter, Matthew W. B., Smith, James C., Pedersen, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Stem Cells and Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483767/
https://www.ncbi.nlm.nih.gov/pubmed/26015544
http://dx.doi.org/10.1242/dev.117838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483767/
https://www.ncbi.nlm.nih.gov/pubmed/26015544
http://dx.doi.org/10.1242/dev.117838

Ejemplares similares