Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway

Chondrosarcoma is a malignant tumor that produces cartilage matrix. The most lethal aspect is its metastatic property. We demonstrated that amphiregulin (AR) is significantly upregulated in highly aggressive cells. AR silencing markedly suppressed cell migration. Exogenous AR markedly increased cell...

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Detalles Bibliográficos
Autores principales: Chen, Jui-Chieh, Chen, Yu-Ju, Lin, Chih-Yang, Fong, Yi-Chin, Hsu, Chin-Jung, Tsai, Chun-Hao, Su, Jen-Liang, Tang, Chih-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484467/
https://www.ncbi.nlm.nih.gov/pubmed/25825984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484467/
https://www.ncbi.nlm.nih.gov/pubmed/25825984

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