MTH1 expression is required for effective transformation by oncogenic HRAS

Due to sustaining elevated reactive oxygen species (ROS), oncogenic RAS-transformed cells upregulate redox-protective genes, among them the mammalian 8-oxodGTPase, MutT Homolog 1 (MTH1). We previously showed MTH1 abrogates RAS oncogene-induced senescence (OIS) in normal cells and that its inhibition...

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Detalles Bibliográficos
Autores principales: Giribaldi, Maria G., Munoz, Anisleidys, Halvorsen, Katherine, Patel, Asmita, Rai, Priyamvada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484473/
https://www.ncbi.nlm.nih.gov/pubmed/25893378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484473/
https://www.ncbi.nlm.nih.gov/pubmed/25893378

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