AMD3100 reduces CXCR4-mediated survival and metastasis of osteosarcoma by inhibiting JNK and Akt, but not p38 or Erk1/2, pathways in in vitro and mouse experiments

Osteosarcoma (OS) has an unfavorable prognosis and tends to metastasize to lung tissue. Although the CXCL12-CXCR4 axis appears to affect progression and metastasis in numerous tumors, its mechanism and downstream pathways in OS remain unclear. We used western blotting and flow cytometry to detect CX...

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Detalles Bibliográficos
Autores principales: LIAO, YU-XIN, FU, ZE-ZE, ZHOU, CHENG-HAO, SHAN, LIAN-CHENG, WANG, ZHUO-YING, YIN, FEI, ZHENG, LONG-PO, HUA, YING-QI, CAI, ZHENG-DONG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484610/
https://www.ncbi.nlm.nih.gov/pubmed/25997540
http://dx.doi.org/10.3892/or.2015.3992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484610/
https://www.ncbi.nlm.nih.gov/pubmed/25997540
http://dx.doi.org/10.3892/or.2015.3992

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