Cargando…

DICER Inactivation Identifies Pancreatic β-Cell “Disallowed” Genes Targeted by MicroRNAs

Pancreatic β-cells are the body's sole source of circulating insulin and essential for the maintenance of blood glucose homeostasis. Levels of up to 66 “disallowed” genes, which are strongly expressed and play housekeeping roles in most other mammalian tissues, are unusually low in β-cells. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martinez-Sanchez, Aida, Nguyen-Tu, Marie-Sophie, Rutter, Guy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484783/ https://www.ncbi.nlm.nih.gov/pubmed/26038943 http://dx.doi.org/10.1210/me.2015-1059

Ejemplares similares

Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity
por: Rutter, Guy A., et al.
Publicado: (2020)

Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene
por: Pullen, Timothy J., et al.
Publicado: (2017)

Dicer and microRNAs protect adult dopamine neurons
por: Chmielarz, Piotr, et al.
Publicado: (2017)

How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress?
por: Lemaire, Katleen, et al.
Publicado: (2017)

Molecular Mechanisms of Nutrient-Mediated Regulation of MicroRNAs in Pancreatic β-cells
por: Sałówka, Anna, et al.
Publicado: (2021)

Factors associated with disallowance of compulsory mental healthcare referrals
por: Fuglseth, N. L. D., et al.
Publicado: (2016)

Structural interrogation of phosphoproteome identified by mass spectrometry reveals allowed and disallowed regions of phosphoconformation
por: Somavarapu, Arun Kumar, et al.
Publicado: (2014)

IsomiR expression patterns in canonical and Dicer-independent microRNAs
por: Liang, Tingming, et al.
Publicado: (2017)

MicroRNA processing without Dicer
por: Dueck, Anne, et al.
Publicado: (2010)

Processing of Pre-microRNAs by the Dicer-1–Loquacious Complex in Drosophila Cells
por: Saito, Kuniaki, et al.
Publicado: (2005)

Serum levels of mature microRNAs in DICER1-mutated pleuropulmonary blastoma
por: Murray, M J, et al.
Publicado: (2014)

The HDAC Inhibitor Butyrate Impairs β Cell Function and Activates the Disallowed Gene Hexokinase I
por: Bridgeman, Stephanie, et al.
Publicado: (2021)

Dicer-Derived MicroRNAs Are Utilized by the Fragile X Mental Retardation Protein for Assembly on Target RNAs
por: Plante, Isabelle, et al.
Publicado: (2006)

Reversible Block of Mouse Neural Stem Cell Differentiation in the Absence of Dicer and MicroRNAs
por: Andersson, Therese, et al.
Publicado: (2010)

Major regulators of microRNAs biogenesis Dicer and Drosha are down-regulated in endometrial cancer
por: Torres, Anna, et al.
Publicado: (2011)

MiRNAs in β-Cell Development, Identity, and Disease
por: Martinez-Sanchez, Aida, et al.
Publicado: (2017)

Infections of virulent and avirulent viruses differentially influenced the expression of dicer-1, ago-1, and microRNAs in Bombus terrestris
por: Niu, Jinzhi, et al.
Publicado: (2017)

β-catenin mediates behavioral resilience through Dicer1/microRNA regulation
por: Dias, Caroline, et al.
Publicado: (2014)

Dicer-Dependent Biogenesis of Small RNAs and Evidence for MicroRNA-Like RNAs in the Penicillin Producing Fungus Penicillium chrysogenum
por: Dahlmann, Tim A., et al.
Publicado: (2015)

Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets
por: Tugay, Ksenia, et al.
Publicado: (2015)

Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development
por: Vishlaghi, Neda, et al.
Publicado: (2020)

The microRNA-Processing Enzyme Dicer Is Essential for Thyroid Function
por: Frezzetti, Daniela, et al.
Publicado: (2011)

The Role of Dicer Protein Partners in the Processing of MicroRNA Precursors
por: Koscianska, Edyta, et al.
Publicado: (2011)

Derivation and characterization of Dicer- and microRNA-deficient human cells
por: Bogerd, Hal P., et al.
Publicado: (2014)

Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer
por: Zhang, Xiaoxiao, et al.
Publicado: (2022)

Structural and functional basis of mammalian microRNA biogenesis by Dicer
por: Zapletal, David, et al.
Publicado: (2022)

An Economic Evaluation of Disallowing Body Checking in 11- to 12-Year-Old Ice Hockey Leagues
por: Currie, Gillian R., et al.
Publicado: (2021)

Analysis of the Maize dicer-like1 Mutant, fuzzy tassel, Implicates MicroRNAs in Anther Maturation and Dehiscence
por: Field, Sterling, et al.
Publicado: (2016)

MicroRNAs in Hepatobiliary and Pancreatic Cancers
por: Saito, Yoshimasa, et al.
Publicado: (2011)

Global Switch from DICER-dependent MicroRNA to DICER-independent SnoRNA-derived RNA Biogenesis in Malignancy
por: Godang, Noel L, et al.
Publicado: (2023)

Dicer-dependent microRNA pathway safeguards regulatory T cell function
por: Liston, Adrian, et al.
Publicado: (2008)

The terminal loop region controls microRNA processing by Drosha and Dicer
por: Zhang, Xiaoxiao, et al.
Publicado: (2010)

MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer
por: Johanson, Timothy M., et al.
Publicado: (2013)

Functional Profiling of Precursor MicroRNAs Identifies MicroRNAs Essential for Glioma Proliferation
por: Haapa-Paananen, Saija, et al.
Publicado: (2013)

Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function
por: López–Noriega, Livia, et al.
Publicado: (2021)

Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients
por: Gazon, Hélène, et al.
Publicado: (2016)

Tendon-Specific Dicer Deficient Mice Exhibit Hypoplastic Tendon Through the Downregulation of Tendon-Related Genes and MicroRNAs
por: Omoto, Takenori, et al.
Publicado: (2022)

MicroRNAs in pancreatic cancer diagnosis and therapy
por: Słotwiński, Robert, et al.
Publicado: (2018)

The Role of MicroRNAs in Pancreatitis Development and Progression
por: Patel, Hetvi R., et al.
Publicado: (2023)

Network of microRNAs-mRNAs Interactions in Pancreatic Cancer
por: Naderi, Elnaz, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_vnunmoim25732hddra6q092sj4