DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

Alterations in cerebral cortex connectivity lead to intellectual disability and in Down syndrome, this is associated with a deficit in cortical neurons that arises during prenatal development. However, the pathogenic mechanisms that cause this deficit have not yet been defined. Here we show that the...

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Detalles Bibliográficos
Autores principales: Najas, Sònia, Arranz, Juan, Lochhead, Pamela A., Ashford, Anne L., Oxley, David, Delabar, Jean M., Cook, Simon J., Barallobre, María José, Arbonés, Maria L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484814/
https://www.ncbi.nlm.nih.gov/pubmed/26137553
http://dx.doi.org/10.1016/j.ebiom.2015.01.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484814/
https://www.ncbi.nlm.nih.gov/pubmed/26137553
http://dx.doi.org/10.1016/j.ebiom.2015.01.010

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