Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma

The tumor microenvironment is characterized by deficiencies in oxygen and nutrients, such as glucose and amino acids. Activation of the GCN2 arm of the Integrated Stress Response (ISR) in response to amino acid deprivation is one mechanism by which tumor cells cope with nutrient stress. GCN2 phospho...

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Detalles Bibliográficos
Autores principales: Lehman, Stacey L., Ryeom, Sandra, Koumenis, Constantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485314/
https://www.ncbi.nlm.nih.gov/pubmed/26123823
http://dx.doi.org/10.1038/srep11781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485314/
https://www.ncbi.nlm.nih.gov/pubmed/26123823
http://dx.doi.org/10.1038/srep11781

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