Trbp regulates heart function through miRNA-mediated Sox6 repression

Cardiomyopathy is associated with altered expression of genes encoding contractile proteins. Here we show that Trbp (Tarbp2), an RNA binding protein, is required for normal heart function. Cardiac-specific inactivation of Trbp (Trbp(cKO)) caused progressive cardiomyopathy and lethal heart failure. T...

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Detalles Bibliográficos
Autores principales: Ding, Jian, Chen, Jinghai, Wang, Yanqun, Kataoka, Masaharu, Ma, Lixin, Zhou, Pingzhu, Hu, Xiaoyun, Lin, Zhiqiang, Nie, Mao, Deng, Zhong-Liang, Pu, William T, Wang, Da-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485565/
https://www.ncbi.nlm.nih.gov/pubmed/26029872
http://dx.doi.org/10.1038/ng.3324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485565/
https://www.ncbi.nlm.nih.gov/pubmed/26029872
http://dx.doi.org/10.1038/ng.3324

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