Modulating gut immunity and neoplasia with oral cytokine adjuvants

Oral administration of particulate IL-10 suppressed polyposis, ameliorated systemic pathology and extended lifespan in APC(min/+) mice. Therapeutic effect was associated with selective activity of IL-10 on intestinal CD4+Foxp3+RORγt+IL-17+ pathogenic T-regulatory cells. Studies were recently extende...

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Autores principales: Ozbilge, Hatice, LeVea, Charles, Chung, Allen Y, Li, Qingsheng, Egilmez, Nejat K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485710/
https://www.ncbi.nlm.nih.gov/pubmed/26137401
http://dx.doi.org/10.1080/2162402X.2014.1002724
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author Ozbilge, Hatice
LeVea, Charles
Chung, Allen Y
Li, Qingsheng
Egilmez, Nejat K
author_facet Ozbilge, Hatice
LeVea, Charles
Chung, Allen Y
Li, Qingsheng
Egilmez, Nejat K
author_sort Ozbilge, Hatice
collection PubMed
description Oral administration of particulate IL-10 suppressed polyposis, ameliorated systemic pathology and extended lifespan in APC(min/+) mice. Therapeutic effect was associated with selective activity of IL-10 on intestinal CD4+Foxp3+RORγt+IL-17+ pathogenic T-regulatory cells. Studies were recently extended to a bacterially-driven murine colon adenocarcinoma model with similar results. Clinical implications of these findings are discussed.
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spelling pubmed-44857102016-01-22 Modulating gut immunity and neoplasia with oral cytokine adjuvants Ozbilge, Hatice LeVea, Charles Chung, Allen Y Li, Qingsheng Egilmez, Nejat K Oncoimmunology Author's View Oral administration of particulate IL-10 suppressed polyposis, ameliorated systemic pathology and extended lifespan in APC(min/+) mice. Therapeutic effect was associated with selective activity of IL-10 on intestinal CD4+Foxp3+RORγt+IL-17+ pathogenic T-regulatory cells. Studies were recently extended to a bacterially-driven murine colon adenocarcinoma model with similar results. Clinical implications of these findings are discussed. Taylor & Francis 2015-01-22 /pmc/articles/PMC4485710/ /pubmed/26137401 http://dx.doi.org/10.1080/2162402X.2014.1002724 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Ozbilge, Hatice
LeVea, Charles
Chung, Allen Y
Li, Qingsheng
Egilmez, Nejat K
Modulating gut immunity and neoplasia with oral cytokine adjuvants
title Modulating gut immunity and neoplasia with oral cytokine adjuvants
title_full Modulating gut immunity and neoplasia with oral cytokine adjuvants
title_fullStr Modulating gut immunity and neoplasia with oral cytokine adjuvants
title_full_unstemmed Modulating gut immunity and neoplasia with oral cytokine adjuvants
title_short Modulating gut immunity and neoplasia with oral cytokine adjuvants
title_sort modulating gut immunity and neoplasia with oral cytokine adjuvants
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485710/
https://www.ncbi.nlm.nih.gov/pubmed/26137401
http://dx.doi.org/10.1080/2162402X.2014.1002724
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