Restoration of defective cross-presentation in tumors by gemcitabine

Tumor antigen cross-presentation by dendritic cells (DCs) to specific CD8(+) T cells is central to antitumor immunity. Although highly efficient in draining lymph nodes, it is defective within the tumor site itself. Importantly, an immunogenic chemotherapy, gemcitabine, reverses this defect, allowin...

Descripción completa

Detalles Bibliográficos
Autores principales: McDonnell, Alison M, Joost Lesterhuis, W, Khong, Andrea, Nowak, Anna K, Lake, Richard A, Currie, Andrew J, Robinson, Bruce WS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485774/
https://www.ncbi.nlm.nih.gov/pubmed/26155402
http://dx.doi.org/10.1080/2162402X.2015.1005501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485774/
https://www.ncbi.nlm.nih.gov/pubmed/26155402
http://dx.doi.org/10.1080/2162402X.2015.1005501

Ejemplares similares