Restoration of defective cross-presentation in tumors by gemcitabine

Tumor antigen cross-presentation by dendritic cells (DCs) to specific CD8(+) T cells is central to antitumor immunity. Although highly efficient in draining lymph nodes, it is defective within the tumor site itself. Importantly, an immunogenic chemotherapy, gemcitabine, reverses this defect, allowin...

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Detalles Bibliográficos
Autores principales: McDonnell, Alison M, Joost Lesterhuis, W, Khong, Andrea, Nowak, Anna K, Lake, Richard A, Currie, Andrew J, Robinson, Bruce WS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485774/
https://www.ncbi.nlm.nih.gov/pubmed/26155402
http://dx.doi.org/10.1080/2162402X.2015.1005501
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author McDonnell, Alison M
Joost Lesterhuis, W
Khong, Andrea
Nowak, Anna K
Lake, Richard A
Currie, Andrew J
Robinson, Bruce WS
author_facet McDonnell, Alison M
Joost Lesterhuis, W
Khong, Andrea
Nowak, Anna K
Lake, Richard A
Currie, Andrew J
Robinson, Bruce WS
author_sort McDonnell, Alison M
collection PubMed
description Tumor antigen cross-presentation by dendritic cells (DCs) to specific CD8(+) T cells is central to antitumor immunity. Although highly efficient in draining lymph nodes, it is defective within the tumor site itself. Importantly, an immunogenic chemotherapy, gemcitabine, reverses this defect, allowing the potential re-stimulation of cytotoxic T lymphocytes within tumor sites.
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spelling pubmed-44857742016-02-03 Restoration of defective cross-presentation in tumors by gemcitabine McDonnell, Alison M Joost Lesterhuis, W Khong, Andrea Nowak, Anna K Lake, Richard A Currie, Andrew J Robinson, Bruce WS Oncoimmunology Author's View Tumor antigen cross-presentation by dendritic cells (DCs) to specific CD8(+) T cells is central to antitumor immunity. Although highly efficient in draining lymph nodes, it is defective within the tumor site itself. Importantly, an immunogenic chemotherapy, gemcitabine, reverses this defect, allowing the potential re-stimulation of cytotoxic T lymphocytes within tumor sites. Taylor & Francis 2015-02-25 /pmc/articles/PMC4485774/ /pubmed/26155402 http://dx.doi.org/10.1080/2162402X.2015.1005501 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
McDonnell, Alison M
Joost Lesterhuis, W
Khong, Andrea
Nowak, Anna K
Lake, Richard A
Currie, Andrew J
Robinson, Bruce WS
Restoration of defective cross-presentation in tumors by gemcitabine
title Restoration of defective cross-presentation in tumors by gemcitabine
title_full Restoration of defective cross-presentation in tumors by gemcitabine
title_fullStr Restoration of defective cross-presentation in tumors by gemcitabine
title_full_unstemmed Restoration of defective cross-presentation in tumors by gemcitabine
title_short Restoration of defective cross-presentation in tumors by gemcitabine
title_sort restoration of defective cross-presentation in tumors by gemcitabine
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485774/
https://www.ncbi.nlm.nih.gov/pubmed/26155402
http://dx.doi.org/10.1080/2162402X.2015.1005501
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