NG2 proteoglycan-dependent recruitment of tumor macrophages promotes pericyte-endothelial cell interactions required for brain tumor vascularization

Early stage growth of intracranial B16F10 tumors is reduced by 87% in myeloid-specific NG2 null (Mac-NG2ko) mice and by 77% in pericyte-specific NG2 null (PC-NG2ko) mice, demonstrating the importance of the NG2 proteoglycan in each of these stromal compartments. In both genotypes, loss of pericyte-e...

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Detalles Bibliográficos
Autores principales: Yotsumoto, Fusanori, You, Weon-Kyoo, Cejudo-Martin, Pilar, Kucharova, Karolina, Sakimura, Kenji, Stallcup, William B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485789/
https://www.ncbi.nlm.nih.gov/pubmed/26137396
http://dx.doi.org/10.1080/2162402X.2014.1001204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485789/
https://www.ncbi.nlm.nih.gov/pubmed/26137396
http://dx.doi.org/10.1080/2162402X.2014.1001204

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