Shaping the tumor microenvironment with Modified Vaccinia Virus Ankara and TLR9 ligand

Our preclinical data demonstrate that an intravenous injection of Modified Vaccinia virus Ankara induces CD8(+) lymphocytes to infiltrate organs to control the growth of orthotopic renal carcinoma upon combination with a toll-like receptor 9 agonist. Such shaping of the tumor microenvironment could...

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Detalles Bibliográficos
Autores principales: Préville, Xavier, Rittner, Karola, Fend, Laetitia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485804/
https://www.ncbi.nlm.nih.gov/pubmed/26155396
http://dx.doi.org/10.1080/2162402X.2014.1003013
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author Préville, Xavier
Rittner, Karola
Fend, Laetitia
author_facet Préville, Xavier
Rittner, Karola
Fend, Laetitia
author_sort Préville, Xavier
collection PubMed
description Our preclinical data demonstrate that an intravenous injection of Modified Vaccinia virus Ankara induces CD8(+) lymphocytes to infiltrate organs to control the growth of orthotopic renal carcinoma upon combination with a toll-like receptor 9 agonist. Such shaping of the tumor microenvironment could constitute the basis of more effective clinical protocols of tumor immunotherapy.
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spelling pubmed-44858042016-02-03 Shaping the tumor microenvironment with Modified Vaccinia Virus Ankara and TLR9 ligand Préville, Xavier Rittner, Karola Fend, Laetitia Oncoimmunology Author's View Our preclinical data demonstrate that an intravenous injection of Modified Vaccinia virus Ankara induces CD8(+) lymphocytes to infiltrate organs to control the growth of orthotopic renal carcinoma upon combination with a toll-like receptor 9 agonist. Such shaping of the tumor microenvironment could constitute the basis of more effective clinical protocols of tumor immunotherapy. Taylor & Francis 2015-02-03 /pmc/articles/PMC4485804/ /pubmed/26155396 http://dx.doi.org/10.1080/2162402X.2014.1003013 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Préville, Xavier
Rittner, Karola
Fend, Laetitia
Shaping the tumor microenvironment with Modified Vaccinia Virus Ankara and TLR9 ligand
title Shaping the tumor microenvironment with Modified Vaccinia Virus Ankara and TLR9 ligand
title_full Shaping the tumor microenvironment with Modified Vaccinia Virus Ankara and TLR9 ligand
title_fullStr Shaping the tumor microenvironment with Modified Vaccinia Virus Ankara and TLR9 ligand
title_full_unstemmed Shaping the tumor microenvironment with Modified Vaccinia Virus Ankara and TLR9 ligand
title_short Shaping the tumor microenvironment with Modified Vaccinia Virus Ankara and TLR9 ligand
title_sort shaping the tumor microenvironment with modified vaccinia virus ankara and tlr9 ligand
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485804/
https://www.ncbi.nlm.nih.gov/pubmed/26155396
http://dx.doi.org/10.1080/2162402X.2014.1003013
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