A Hot-spot of In-frame Duplications Activates the Oncoprotein AKT1 in Juvenile Granulosa Cell Tumors

BACKGROUND: Ovarian granulosa cell tumors are the most common sex-cord stromal tumors and have juvenile (JGCTs) and adult forms. In a previous study we reported the occurrence of activating somatic mutations of Gαs, which transduces mitogenic signals, in 30% of the analyzed JGCTs. METHODS: We have s...

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Detalles Bibliográficos
Autores principales: Bessière, Laurianne, Todeschini, Anne-Laure, Auguste, Aurélie, Sarnacki, Sabine, Flatters, Delphine, Legois, Bérangère, Sultan, Charles, Kalfa, Nicolas, Galmiche, Louise, Veitia, Reiner A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485906/
https://www.ncbi.nlm.nih.gov/pubmed/26137586
http://dx.doi.org/10.1016/j.ebiom.2015.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485906/
https://www.ncbi.nlm.nih.gov/pubmed/26137586
http://dx.doi.org/10.1016/j.ebiom.2015.03.002

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