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Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD
An evolutionarily conserved unfolded protein response (UPR) component, IRE1, cleaves XBP1/HAC1 introns in order to generate spliced mRNAs that are translated into potent transcription factors. IRE1 also cleaves endoplasmic-reticulum-associated RNAs leading to their decay, an activity termed regulate...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486022/ https://www.ncbi.nlm.nih.gov/pubmed/25437541 http://dx.doi.org/10.1016/j.celrep.2014.09.016 |