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Construction and applications of exon-trapping gene-targeting vectors with a novel strategy for negative selection
BACKGROUND: Targeted gene modification by homologous recombination provides a powerful tool for studying gene function in cells and animals. In higher eukaryotes, non-homologous integration of targeting vectors occurs several orders of magnitude more frequently than does targeted integration, making...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486125/ https://www.ncbi.nlm.nih.gov/pubmed/26123730 http://dx.doi.org/10.1186/s13104-015-1241-6 |