Halofuginone inhibits phosphorylation of SMAD-2 reducing angiogenesis and leukemia burden in an acute promyelocytic leukemia mouse model

BACKGROUND: Halofuginone (HF) is a low-molecular-weight alkaloid that has been demonstrated to interfere with Metalloproteinase-2 (MMP-2) and Tumor Growth Factor-β (TGF-β) function and, to present antiangiogenic, antiproliferative and proapoptotic properties in several solid tumor models. Based on t...

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Detalles Bibliográficos
Autores principales: Assis, Patricia A., De Figueiredo-Pontes, Lorena L., Lima, Ana Silvia G., Leão, Vitor, Cândido, Larissa A., Pintão, Carolina T., Garcia, Aglair B., Saggioro, Fabiano P., Panepucci, Rodrigo A, Chahud, Fernando, Nagler, Arnon, Falcão, Roberto P., Rego, Eduardo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486128/
https://www.ncbi.nlm.nih.gov/pubmed/26099922
http://dx.doi.org/10.1186/s13046-015-0181-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486128/
https://www.ncbi.nlm.nih.gov/pubmed/26099922
http://dx.doi.org/10.1186/s13046-015-0181-2

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