Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4–MLL Fusion Protein

We have recently demonstrated that Taspase1-mediated cleavage of the AF4–MLL oncoprotein results in the formation of a stable multiprotein complex which forms the key event for the onset of acute proB leukemia in mice. Therefore, Taspase1 represents a conditional oncoprotein in the context of t(4;11...

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Detalles Bibliográficos
Autores principales: Sabiani, Samaneh, Geppert, Tim, Engelbrecht, Christian, Kowarz, Eric, Schneider, Gisbert, Marschalek, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486195/
https://www.ncbi.nlm.nih.gov/pubmed/26137584
http://dx.doi.org/10.1016/j.ebiom.2015.04.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486195/
https://www.ncbi.nlm.nih.gov/pubmed/26137584
http://dx.doi.org/10.1016/j.ebiom.2015.04.009

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