LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small cell lung cancer (NSCLC) cells

The tumor suppressor serine/threonine kinase 11 (STK11 or LKB1) is mutated in 20–30% of non-small cell lung cancer (NSCLC) patient tumors. Loss of LKB1-AMPK signaling confers sensitivity to metabolic inhibition or stress-induced mitochondrial insults. We tested the hypothesis that loss of LKB1 sensi...

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Detalles Bibliográficos
Autores principales: Whang, Young Mi, Park, Serk In, Trenary, Irina A., Egnatchik, Robert A., Fessel, Joshua P., Kaufman, Jacob M., Carbone, David P., Young, Jamey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486321/
https://www.ncbi.nlm.nih.gov/pubmed/26119936
http://dx.doi.org/10.1038/onc.2015.140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486321/
https://www.ncbi.nlm.nih.gov/pubmed/26119936
http://dx.doi.org/10.1038/onc.2015.140

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