Cargando…

Models in biology: lessons from modeling regulation of the eukaryotic cell cycle

In this essay we illustrate some general principles of mathematical modeling in biology by our experiences in studying the molecular regulatory network underlying eukaryotic cell division. We discuss how and why the models moved from simple, parsimonious cartoons to more complex, detailed mechanisms...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tyson, John J., Novák, Béla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486427/ https://www.ncbi.nlm.nih.gov/pubmed/26129844 http://dx.doi.org/10.1186/s12915-015-0158-9

Ejemplares similares

A model of yeast cell-cycle regulation based on multisite phosphorylation
por: Barik, Debashis, et al.
Publicado: (2010)

Dynamical modeling of syncytial mitotic cycles in Drosophila embryos
por: Calzone, Laurence, et al.
Publicado: (2007)

Time-keeping and decision-making in the cell cycle
por: Tyson, John J., et al.
Publicado: (2022)

Dilution and titration of cell-cycle regulators may control cell size in budding yeast
por: Heldt, Frank S., et al.
Publicado: (2018)

Mitotic kinase oscillation governs the latching of cell cycle switches
por: Novak, Bela, et al.
Publicado: (2022)

Saccharomyces cerevisiae as a Model System for Eukaryotic Cell Biology, from Cell Cycle Control to DNA Damage Response
por: Vanderwaeren, Laura, et al.
Publicado: (2022)

Cell-cycle transitions: a common role for stoichiometric inhibitors
por: Hopkins, Michael, et al.
Publicado: (2017)

Cell Cycle Control by a Minimal Cdk Network
por: Gérard, Claude, et al.
Publicado: (2015)

Molecular mechanisms creating bistable switches at cell cycle transitions
por: Verdugo, Anael, et al.
Publicado: (2013)

Computational modeling of chromosome re-replication in mutant strains of fission yeast
por: Novák, Béla, et al.
Publicado: (2021)

Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation
por: Csikász-Nagy, Attila, et al.
Publicado: (2009)

Mathematical model of the morphogenesis checkpoint in budding yeast
por: Ciliberto, Andrea, et al.
Publicado: (2003)

A Hybrid Model of Mammalian Cell Cycle Regulation
por: Singhania, Rajat, et al.
Publicado: (2011)

Cyanidioschyzon merolae: A New Model Eukaryote for Cell and Organelle Biology
por: Parker, Termara
Publicado: (2019)

The biosynthesis of phospholipids is linked to the cell cycle in a model eukaryote
por: Vítová, Milada, et al.
Publicado: (2021)

Defensins: antifungal lessons from eukaryotes
por: Silva, Patrícia M., et al.
Publicado: (2014)

Breaking the cycle: An insight into the role of ERα in eukaryotic cell cycles
por: Moghadam, Sonia Javan, et al.
Publicado: (2011)

Biology of Obesity: Lessons from Animal Models of Obesity
por: Kanasaki, Keizo, et al.
Publicado: (2011)

A Model of Yeast Cell-Cycle Regulation Based on a Standard Component Modeling Strategy for Protein Regulatory Networks
por: Laomettachit, Teeraphan, et al.
Publicado: (2016)

Regulation of Mitotic Exit by Cell Cycle Checkpoints: Lessons From Saccharomyces cerevisiae
por: Matellán, Laura, et al.
Publicado: (2020)

A Stochastic Model of the Yeast Cell Cycle Reveals Roles for Feedback Regulation in Limiting Cellular Variability
por: Barik, Debashis, et al.
Publicado: (2016)

A hybrid stochastic model of the budding yeast cell cycle
por: Ahmadian, Mansooreh, et al.
Publicado: (2020)

A stochastic model of size control in the budding yeast cell cycle
por: Ahmadian, Mansooreh, et al.
Publicado: (2019)

Time scale and dimension analysis of a budding yeast cell cycle model
por: Lovrics, Anna, et al.
Publicado: (2006)

Unraveling Adaptation in Eukaryotic Pathways: Lessons from Protocells
por: De Palo, Giovanna, et al.
Publicado: (2013)

Overexpression limits of fission yeast cell-cycle regulators in vivo and in silico
por: Moriya, Hisao, et al.
Publicado: (2011)

Computational modeling of unphosphorylated CtrA:Cori binding in the Caulobacter cell cycle
por: Weston, Bronson R., et al.
Publicado: (2021)

Perspectives in Cell Cycle Regulation: Lessons from an Anoxic Vertebrate
por: Biggar, Kyle K., et al.
Publicado: (2009)

A Comparison of Computational Models for Eukaryotic Cell Shape and Motility
por: Holmes, William R., et al.
Publicado: (2012)

Characterization and Evolution of the Cell Cycle-Associated Mob Domain-Containing Proteins in Eukaryotes
por: Vitulo, Nicola, et al.
Publicado: (2007)

Core control principles of the eukaryotic cell cycle
por: Basu, Souradeep, et al.
Publicado: (2022)

Modern Cell Biology. Volume 2. Spatial Organization of Eukaryotic Cells
por: Barrnett, Russell J.
Publicado: (1983)

Regulation of the cell cycle and centrosome biology by deubiquitylases
por: Darling, Sarah, et al.
Publicado: (2017)

Eukaryotic systems broaden the scope of synthetic biology
por: Haynes, Karmella A., et al.
Publicado: (2009)

Cell cycle commitment in budding yeast emerges from the cooperation of multiple bistable switches
por: Zhang, Tongli, et al.
Publicado: (2011)

Lessons and perspectives for applications of stochastic models in biological and cancer research
por: Sabino, Alan U, et al.
Publicado: (2018)

Fission yeast cell cycle mutants and the logic of eukaryotic cell cycle control
por: Nurse, Paul
Publicado: (2020)

Epigenetic Regulation of ALS and CMT: A Lesson from Drosophila Models
por: Yamaguchi, Masamitsu, et al.
Publicado: (2021)

Eukaryotic Cell Membranes: Structure, Composition, Research Methods and Computational Modelling
por: Zhukov, Anatoly, et al.
Publicado: (2023)

Measurement and modeling of transcriptional noise in the cell cycle regulatory network
por: Ball, David A, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_c3bp6fhlvreofbkjk0a7vsifgq