Highly homologous proteins exert opposite biological activities by using different interaction interfaces

We present a possible molecular basis for the opposite activity of two homologues proteins that bind similar ligands and show that this is achieved by fine-tuning of the interaction interface. The highly homologous ASPP proteins have opposite roles in regulating apoptosis: ASPP2 induces apoptosis wh...

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Detalles Bibliográficos
Autores principales: Iosub Amir, Anat, van Rosmalen, Martijn, Mayer, Guy, Lebendiker, Mario, Danieli, Tsafi, Friedler, Assaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486954/
https://www.ncbi.nlm.nih.gov/pubmed/26130271
http://dx.doi.org/10.1038/srep11629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486954/
https://www.ncbi.nlm.nih.gov/pubmed/26130271
http://dx.doi.org/10.1038/srep11629

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